[GET] Harrison's Principles of Internal Medicine

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Part 1: The Profession of Medicine
Chapter 1: The Practice of Medicine
Chapter 2: Promoting Good Health
Chapter 3: Vaccine Opposition and Hesitancy
Chapter 4: Decision-Making in Clinical Medicine
Chapter 5: Precision Medicine and Clinical Care
Chapter 6: Screening and Prevention of Disease
Chapter 7: Global Diversity of Health System Financing and Delivery
Chapter 8: The Safety and Quality of Health Care
Chapter 9: Diagnosis: Reducing Errors and Improving Quality
Chapter 10: Racial and Ethnic Disparities in Health Care
Chapter 11: Ethical Issues in Clinical Medicine
Chapter 12: Palliative and End-of-Life Care

Part 2: Cardinal Manifestations and Presentation of Diseases
Section 1: Pain
Chapter 13: Pain: Pathophysiology and Management
Updated! Chapter 16: Headache
Chapter 14: Chest Discomfort
Chapter 15: Abdominal Pain
Chapter 17: Back and Neck Pain
Section 2: Alterations in Body Temperature
Chapter 18: Fever
Chapter 19: Fever and Rash
Chapter 20: Fever of Unknown Origin

Section 3: Nervous System Dysfunction
Chapter 21: Syncope
Chapter 22: Dizziness and Vertigo
Chapter 23: Fatigue
Chapter 24: Neurologic Causes of Weakness and Paralysis
Chapter 25: Numbness, Tingling, and Sensory Loss
Chapter 26: Gait Disorders, Imbalance, and Falls
Chapter 27: Confusion and Delirium
Chapter 28: Coma
Chapter 29: Dementia
Chapter 30: Aphasia, Memory Loss, and Other Cognitive Disorders
Chapter 31: Sleep Disorders

Section 4: Disorders of Eyes, Ears, Nose, and Throat
Chapter 32: Disorders of the Eye
Chapter 33: Disorders of Smell and Taste
Chapter 34: Disorders of Hearing
Chapter 35: Upper Respiratory Symptoms, Including Earache, Sinus Symptoms, and Sore Throat
Chapter 36: Oral Manifestations of Disease

Section 5: Alterations in Circulatory and Respiratory Functions
Chapter 37: Dyspnea
Chapter 38: Cough
Chapter 39: Hemoptysis
Chapter 40: Hypoxia and Cyanosis
Chapter 41: Edema
Chapter 42: Approach to the Patient with a Heart Murmur
Chapter 43: Palpitations

Section 6: Alterations in Gastrointestinal Function
Chapter 44: Dysphagia
Chapter 45: Nausea, Vomiting, and Indigestion
Chapter 46: Diarrhea and Constipation
Chapter 47: Unintentional Weight Loss
Chapter 48: Gastrointestinal Bleeding
Chapter 49: Jaundice
Chapter 50: Abdominal Swelling and Ascites

Section 7: Alterations in Renal and Urinary Tract Function
Chapter 51: Interstitial Cystitis/Bladder Pain Syndrome
Chapter 52: Azotemia and Urinary Abnormalities
Chapter 53: Fluid and Electrolyte Disturbances
Chapter 54: Hypercalcemia and Hypocalcemia
Chapter 55: Acidosis and Alkalosis

Section 8: Alterations in the Skin
Chapter 56: Approach to the Patient with a Skin Disorder
Chapter 57: Eczema, Psoriasis, Cutaneous Infections, Acne, and Other Common Skin Disorders
Chapter 58: Skin Manifestations of Internal Disease
Chapter 59: Immunologically Mediated Skin Diseases
Chapter 60: Cutaneous Drug Reactions
Chapter 61: Photosensitivity and Other Reactions to Sunlight

Section 9: Hematologic Alterations
Chapter 62: Interpreting Peripheral Blood Smears
Chapter 63: Anemia and Polycythemia
Chapter 64: Disorders of Granulocytes and Monocytes
Chapter 65: Bleeding and Thrombosis
Chapter 66: Enlargement of Lymph Nodes and Spleen

Part 3: Pharmacology
Chapter 67: Principles of Clinical Pharmacology
Chapter 68: Pharmacogenomics

Part 4: Oncology and Hematology
Section 1: Neoplastic Disorders
Chapter 69: Approach to the Patient with Cancer
Chapter 70: Prevention and Early Detection of Cancer
Chapter 71: Cancer Genetics
Chapter 72: Cancer Cell Biology
Chapter 73: Principles of Cancer Treatment
Chapter 74: Infections in Patients with Cancer
Chapter 75: Oncologic Emergencies
Chapter 76: Cancer of the Skin
Chapter 77: Head and Neck Cancer
Chapter 78: Neoplasms of the Lung
Chapter 79: Breast Cancer
Chapter 80: Upper Gastrointestinal Tract Cancers
Chapter 81: Lower Gastrointestinal Cancers
Chapter 82: Tumors of the Liver and Biliary Tree
Chapter 83: Pancreatic Cancer
Chapter 84: Gastrointestinal Neuroendocrine Tumors
Chapter 85: Renal Cell Carcinoma
Chapter 86: Cancer of the Bladder and Urinary Tract
Chapter 87: Benign and Malignant Diseases of the Prostate
Chapter 88: Testicular Cancer
Chapter 89: Gynecologic Malignancies
Chapter 90: Primary and Metastatic Tumors of the Nervous System
Chapter 91: Soft Tissue and Bone Sarcomas and Bone Metastases
Chapter 92: Carcinoma of Unknown Primary
Chapter 93: Paraneoplastic Syndromes: Endocrinologic/Hematologic
Chapter 94: Paraneoplastic Neurologic Syndromes and Autoimmune Encephalitis
Chapter 95: Cancer Survivorship and the Long-Term Impact of Cancer and Its Treatment

Section 2: Hematopoietic Disorders
Chapter 96: Hematopoietic Stem Cells
Chapter 97: Iron Deficiency and Other Hypoproliferative Anemias
Chapter 98: Disorders of Hemoglobin
Chapter 99: Megaloblastic Anemias
Chapter 100: Hemolytic Anemias
Chapter 101: Anemia Due to Acute Blood Loss
Chapter 102: Bone Marrow Failure Syndromes Including Aplastic Anemia and Myelodysplasia
Chapter 103: Polycythemia Vera and Other Myeloproliferative Neoplasms
Chapter 104: Acute Myeloid Leukemia
Chapter 105: Chronic Myeloid Leukemia
Chapter 106: Acute Lymphoid Leukemia
Chapter 107: Chronic Lymphocytic Leukemia
Chapter 108: Non-Hodgkin’s Lymphoma
Chapter 109: Hodgkin’s Lymphoma
Chapter 110: Less Common Lymphoid and Myeloid Malignancies
Chapter 111: Plasma Cell Disorders
Chapter 112: Amyloidosis
Chapter 114: Hematopoietic Cell Transplantation
Chapter 113: Transfusion Therapy and Biology

Section 3: Disorders of Hemostasis
Chapter 115: Disorders of Platelets and Vessel Wall
Chapter 116: Coagulation Disorders
Chapter 117: Arterial and Venous Thrombosis
Chapter 118: Antiplatelet, Anticoagulant, and Fibrinolytic Drugs

Part 5: Infectious Diseases
Section 1: Basic Considerations in Infectious Diseases
Chapter 119: Approach to the Patient with an Infectious Disease
Chapter 120: Molecular Mechanisms of Microbial Pathogenesis
Chapter 121: Microbial Genomics and Infectious Disease
Chapter 122: Approach to the Acutely Ill Infected Febrile Patient
Chapter 123: Immunization Principles and Vaccine Use
Chapter 124: Health Recommendations for International Travel
Chapter 125: Climate Change and Infectious Disease

Section 2: Clinical Syndromes: Community-Acquired Infections
Chapter 126: Pneumonia
Chapter 127: Lung Abscess
Chapter 128: Infective Endocarditis
Chapter 129: Infections of the Skin, Muscles, and Soft Tissues
Chapter 130: Infectious Arthritis
Chapter 131: Osteomyelitis
Updated! Chapter 132: Intraabdominal Infections and Abscesses
Chapter 133: Acute Infectious Diarrheal Diseases and Bacterial Food Poisoning
Chapter 134: Clostridioides difficile Infection, Including Pseudomembranous Colitis
Chapter 135: Urinary Tract Infections, Pyelonephritis, and Prostatitis
Chapter 136: Sexually Transmitted Infections: Overview and Clinical Approach
Chapter 137: Encephalitis
Chapter 138: Acute Meningitis
Chapter 139: Chronic and Recurrent Meningitis
Chapter 140: Brain Abscess and Empyema
Chapter 141: Infectious Complications of Bites

Section 3: Clinical Syndromes: Health Care-Associated Infections
Chapter 142: Infections Acquired in Health Care Facilities
Chapter 143: Infections in Transplant Recipients
Section 4: Therapy for Bacterial Diseases
Chapter 144: Treatment and Prophylaxis of Bacterial Infections
Chapter 145: Bacterial Resistance to Antimicrobial Agents
Section 5: Diseases Caused by Gram-Positive Bacteria
Chapter 146: Pneumococcal Infections
Chapter 147: Staphylococcal Infections
Chapter 148: Streptococcal Infections
Chapter 149: Enterococcal Infections
Chapter 150: Diphtheria and Other Corynebacterial Infections
Chapter 151: Listeria monocytogenes Infections
Chapter 152: Tetanus
Chapter 153: Botulism
Chapter 154: Gas Gangrene and Other Clostridial Infections
Section 6: Diseases Caused by Gram-Negative Bacteria
Chapter 155: Meningococcal Infections
Chapter 156: Gonococcal Infections
Chapter 157: Haemophilus and Moraxella Infections
Chapter 158: Infections Due to the HACEK Group and Miscellaneous Gram-Negative Bacteria
Chapter 159: Legionella Infections
Chapter 160: Pertussis and Other Bordetella Infections
Chapter 161: Diseases Caused by Gram-Negative Enteric Bacilli
Chapter 162: Acinetobacter Infections
Chapter 163: Helicobacter pylori Infections
Chapter 164: Infections Due to Pseudomonas, Burkholderia, and Stenotrophomonas Species
Chapter 165: Salmonellosis
Chapter 166: Shigellosis
Chapter 167: Infections Due to Campylobacter and Related Organisms
Chapter 168: Cholera and Other Vibrioses
Chapter 169: Brucellosis
Chapter 170: Tularemia
Chapter 171: Plague and Other Yersinia Infections
Chapter 172: Bartonella Infections, Including Cat-Scratch Disease
Chapter 173: Donovanosis

Section 7: Miscellaneous Bacterial Infections
Chapter 174: Nocardiosis
Chapter 175: Actinomycosis
Chapter 176: Whipple’s Disease
Chapter 177: Infections Due to Mixed Anaerobic Organisms

Section 8: Mycobacterial Diseases
Chapter 178: Tuberculosis
Chapter 179: Leprosy
Chapter 180: Nontuberculous Mycobacterial Infections
Chapter 181: Antimycobacterial Agents

Section 9: Spirochetal Diseases
Chapter 182: Syphilis
Chapter 183: Endemic Treponematoses
Chapter 184: Leptospirosis
Chapter 185: Relapsing Fever and Borrelia miyamotoi Disease
Chapter 186: Lyme Borreliosis

Section 10: Diseases Caused by Rickettsiae, Mycoplasmas, and Chlamydiae
Chapter 187: Rickettsial Diseases
Chapter 188: Infections Due to Mycoplasmas
Chapter 189: Chlamydial Infections

Section 11: Viral Diseases: General Considerations
Chapter 190: Principles of Medical Virology
Chapter 191: Antiviral Chemotherapy, Excluding Antiretroviral Drugs

Section 12: Infections Due to DNA Viruses
Chapter 192: Herpes Simplex Virus Infections
Chapter 193: Varicella-Zoster Virus Infections
Chapter 194: Epstein-Barr Virus Infections, Including Infectious Mononucleosis
Chapter 195: Cytomegalovirus and Human Herpesvirus Types 6, 7, and 8
Chapter 196: Molluscum Contagiosum, Mpox, and Other Poxvirus Infections
Chapter 197: Parvovirus Infections
Chapter 198: Human Papillomavirus Infections

Section 13: Infections Due to DNA and RNA Respiratory Viruses
Chapter 199: Common Viral Respiratory Infections, Including COVID-19
Chapter 200: Influenza

Section 14: Infections Due to Human Immunodeficiency Virus and Other Human Retroviruses
Chapter 201: The Human Retroviruses
Updated! Chapter 202: Human Immunodeficiency Virus Disease: AIDS and Related Disorders

Section 15: Infections Due to RNA Viruses
Chapter 203: Viral Gastroenteritis
Chapter 204: Enterovirus, Parechovirus, and Reovirus Infections
Chapter 205: Measles (Rubeola)
Chapter 206: Rubella (German Measles)
Chapter 207: Mumps
Chapter 208: Rabies and Other Rhabdovirus Infections
Chapter 209: Arthropod-Borne and Rodent-Borne Virus Infections
Chapter 210: Ebolavirus and Marburgvirus Infections

Section 16: Fungal Infections
Chapter 211: Pathogenesis, Diagnosis, and Treatment of Fungal Infections
Chapter 212: Histoplasmosis
Chapter 213: Coccidioidomycosis
Chapter 214: Blastomycosis
Chapter 215: Cryptococcosis
Chapter 216: Candidiasis
Chapter 217: Aspergillosis
Chapter 218: Mucormycosis
Chapter 219: Less Common Systemic Mycoses and Superficial Mycoses
Chapter 220: Pneumocystis Infections

Section 17: Protozoal and Helminthic Infections: General Considerations
Chapter 221: Introduction to Parasitic Infections
Chapter 222: Agents Used to Treat Parasitic Infections

Section 18: Protozoal Infections
Chapter 223: Amebiasis and Infection with Free-Living Amebae
Chapter 224: Malaria
Chapter 225: Babesiosis
Chapter 226: Leishmaniasis
Chapter 227: Chagas Disease and African Trypanosomiasis
Chapter 228: Toxoplasma Infections
Chapter 229: Protozoal Intestinal Infections and Trichomoniasis

Section 19: Helminthic Infections
Chapter 230: Introduction to Helminthic Infections
Chapter 231: Trichinellosis and Other Tissue Nematode Infections
Chapter 232: Intestinal Nematode Infections
Chapter 233: Filarial and Related Infections
Chapter 234: Schistosomiasis and Other Trematode Infections
Chapter 235: Cestode Infections

Part 6: Disorders of the Cardiovascular System
Section 1: Introduction to Cardiovascular Disorders
Chapter 236: Approach to the Patient with Possible Cardiovascular Disease
Chapter 237: Basic Biology of the Cardiovascular System
Chapter 238: Epidemiology of Cardiovascular Disease

Section 2: Diagnosis of Cardiovascular Disorders
Chapter 239: Physical Examination of the Cardiovascular System
Chapter 241: Noninvasive Cardiac Imaging: Echocardiography, Nuclear Cardiology, and Magnetic Resonance/Computed Tomography Imaging
Chapter 240: Electrocardiography
Chapter 242: Diagnostic Cardiac Catheterization and Coronary Angiography

Section 3: Disorders of Rhythm
Chapter 243: Principles of Clinical Cardiac Electrophysiology
Chapter 244: The Bradyarrhythmias: Disorders of the Sinoatrial Node
Chapter 245: The Bradyarrhythmias: Disorders of the Atrioventricular Node
Chapter 246: Approach to Supraventricular Tachyarrhythmias
Chapter 247: Physiologic and Nonphysiologic Sinus Tachycardia
Chapter 248: Focal Atrial Tachycardia
Chapter 249: Paroxysmal Supraventricular Tachycardias
Chapter 250: Common Atrial Flutter and Macroreentrant and Multifocal Atrial Tachycardias
Chapter 251: Atrial Fibrillation
Chapter 252: Approach to Ventricular Arrhythmias
Chapter 253: Premature Ventricular Contractions, Nonsustained Ventricular Tachycardia, and Accelerated Idioventricular Rhythm
Chapter 254: Sustained Ventricular Tachycardia
Chapter 255: Polymorphic Ventricular Tachycardia and Ventricular Fibrillation
Chapter 256: Electrical Storm and Incessant Ventricular Tachycardia

Section 4: Disorders of the Heart, Muscles, Valves, and Pericardium
Chapter 257: Heart Failure: Pathophysiology and Diagnosis
Chapter 258: Heart Failure: Management
Chapter 259: Cardiomyopathy and Myocarditis
Chapter 260: Cardiac Transplantation and Prolonged Assisted Circulation
Chapter 261: Aortic Stenosis
Chapter 262: Aortic Regurgitation
Chapter 263: Mitral Stenosis
Chapter 264: Mitral Regurgitation
Chapter 265: Mitral Valve Prolapse
Chapter 266: Tricuspid Valve Disease
Chapter 267: Pulmonic Valve Disease
Chapter 268: Multiple and Mixed Valvular Heart Disease
Chapter 269: Congenital Heart Disease in the Adult
Chapter 270: Pericardial Disease
Chapter 271: Atrial Myxoma and Other Cardiac Tumors
Chapter 272: Cardiac Trauma

Section 5: Coronary and Peripheral Vascular Disease
Chapter 273: Ischemic Heart Disease
Chapter 274: Non-ST-Segment Elevation Acute Coronary Syndrome (Non-ST-Segment Elevation Myocardial Infarction and Unstable Angina)
Chapter 275: ST-Segment Elevation Myocardial Infarction
Chapter 276: Percutaneous Coronary Interventions and Other Interventional Procedures
Chapter 277: Hypertension
Chapter 278: Renovascular Disease
Chapter 279: Deep-Venous Thrombosis and Pulmonary Thromboembolism
Chapter 280: Diseases of the Aorta
Chapter 281: Arterial Diseases of the Extremities
Chapter 282: Chronic Venous Disease and Lymphedema
Chapter 283: Pulmonary Hypertension

Part 7: Disorders of the Respiratory System
Section 1: Diagnosis of Respiratory Disorders
Chapter 284: Approach to the Patient with Disease of the Respiratory System
Chapter 285: Disturbances of Respiratory Function
Chapter 286: Diagnostic Procedures in Respiratory Disease

Section 2: Diseases of the Respiratory System
Chapter 287: Asthma
Chapter 288: Hypersensitivity Pneumonitis and Pulmonary Infiltrates with Eosinophilia
Chapter 289: Occupational and Environmental Lung Disease
Chapter 290: Bronchiectasis
Chapter 291: Cystic Fibrosis
Chapter 292: Chronic Obstructive Pulmonary Disease
Chapter 293: Interstitial Lung Disease
Chapter 294: Disorders of the Pleura
Chapter 295: Disorders of the Mediastinum
Chapter 296: Disorders of Ventilation
Chapter 297: Sleep Apnea
Chapter 298: Lung Transplantation
Chapter 299: Interventional Pulmonary Medicine

Part 8: Critical Care Medicine
Section 1: Respiratory Critical Care
Chapter 300: Approach to the Patient with Critical Illness
Chapter 301: Acute Respiratory Distress Syndrome
Chapter 302: Mechanical Ventilatory Support
Section 2: Shock and Cardiac Arrest
Chapter 303: Approach to the Patient with Shock
Chapter 304: Sepsis and Septic Shock
Chapter 305: Cardiogenic Shock and Pulmonary Edema
Chapter 306: Cardiovascular Collapse, Cardiac Arrest, and Sudden Cardiac Death
Section 3: Neurologic Critical Care
Chapter 307: Nervous System Disorders in Critical Care

Part 9: Disorders of the Kidney and Urinary Tract
Chapter 308: Approach to the Patient with Renal Disease or Urinary Tract Disease
Chapter 309: Cell Biology and Physiology of the Kidney
Chapter 310: Acute Kidney Injury
Chapter 311: Chronic Kidney Disease
Chapter 312: Dialysis in the Treatment of Kidney Failure
Chapter 313: Transplantation in the Treatment of Renal Failure
Chapter 314: Glomerular Diseases
Chapter 315: Polycystic Kidney Disease and Other Inherited Disorders of Tubule Growth and Development
Chapter 316: Tubulointerstitial Diseases of the Kidney
Chapter 317: Vascular Injury to the Kidney
Chapter 318: Nephrolithiasis
Chapter 319: Urinary Tract Obstruction
Chapter 320: Interventional Nephrology

Part 10: Disorders of the Gastrointestinal System
Section 1: Disorders of the Alimentary Tract
Chapter 321: Approach to the Patient with Gastrointestinal Disease
Chapter 322: Gastrointestinal Endoscopy
Updated! Chapter 323: Diseases of the Esophagus
Chapter 324: Peptic Ulcer Disease and Related Disorders
Chapter 325: Disorders of Absorption
Chapter 326: Inflammatory Bowel Disease
Chapter 327: Irritable Bowel Syndrome
Chapter 328: Diverticular Disease and Common Anorectal Disorders
Chapter 329: Mesenteric Vascular Insufficiency
Chapter 330: Acute Intestinal Obstruction
Chapter 331: Acute Appendicitis and Peritonitis

Section 2: Nutrition
Chapter 332: Nutrient Requirements and Dietary Assessment
Chapter 333: Vitamin and Trace Mineral Deficiency and Excess
Chapter 334: Malnutrition and Nutritional Assessment
Chapter 335: Enteral and Parenteral Nutrition

Section 3: Liver and Biliary Tract Disease
Chapter 336: Approach to the Patient with Liver Disease
Chapter 337: Evaluation of Liver Function
Chapter 338: The Hyperbilirubinemias
Chapter 339: Acute Viral Hepatitis
Chapter 340: Toxic and Drug-Induced Hepatitis
Chapter 341: Chronic Hepatitis
Chapter 342: Alcohol-Associated Liver Disease
Chapter 343: Nonalcoholic Fatty Liver Diseases and Nonalcoholic Steatohepatitis
Chapter 344: Cirrhosis and Its Complications
Chapter 345: Liver Transplantation
Chapter 346: Diseases of the Gallbladder and Bile Ducts

Section 4: Disorders of the Pancreas
Chapter 347: Approach to the Patient with Pancreatic Disease
Chapter 348: Acute and Chronic Pancreatitis

Part 11: Immune-Mediated, Inflammatory, and Rheumatologic Disorders
Section 1: The Immune System in Health and Disease
Chapter 349: Introduction to the Immune System
Chapter 350: Mechanisms of Regulation and Dysregulation of the Immune System
Chapter 351: Primary Immune Deficiency Diseases

Section 2: Disorders of Immune-Mediated Injury
Chapter 352: Urticaria, Angioedema, and Allergic Rhinitis
Chapter 353: Anaphylaxis
Chapter 354: Mastocytosis
Chapter 355: Autoimmunity and Autoimmune Diseases
Chapter 356: Systemic Lupus Erythematosus
Chapter 357: Antiphospholipid Syndrome
Chapter 358: Rheumatoid Arthritis
Chapter 359: Acute Rheumatic Fever
Chapter 360: Systemic Sclerosis (Scleroderma) and Related Disorders
Chapter 361: Sjögren’s Syndrome
Chapter 362: Spondyloarthritis
Chapter 363: The Vasculitis Syndromes
Chapter 364: Behçet Syndrome
Chapter 365: Inflammatory Myopathies
Chapter 366: Relapsing Polychondritis
Chapter 367: Sarcoidosis
Chapter 368: IgG4-Related Disease
Chapter 369: Familial Mediterranean Fever and Other Hereditary Autoinflammatory Diseases

Section 3: Disorders of the Joints and Adjacent Tissues
Chapter 370: Approach to Articular and Musculoskeletal Disorders
Chapter 371: Osteoarthritis
Chapter 372: Gout and Other Crystal-Associated Arthropathies
Chapter 373: Fibromyalgia
Chapter 374: Arthritis Associated with Systemic Disease, and Other Arthritides
Chapter 375: Periarticular Disorders of the Extremities

Part 12: Endocrinology and Metabolism
Section 1: Endocrinology
Chapter 376: Approach to the Patient with Endocrine Disorders
Chapter 377: Mechanisms of Hormone Action
Chapter 378: Physiology of Anterior Pituitary Hormones
Chapter 379: Hypopituitarism
Chapter 380: Pituitary Tumor Syndromes
Chapter 381: Disorders of the Neurohypophysis
Chapter 382: Thyroid Gland Physiology and Testing
Chapter 383: Hypothyroidism
Chapter 384: Hyperthyroidism and Other Causes of Thyrotoxicosis
Chapter 385: Thyroid Nodular Disease and Thyroid Cancer
Chapter 386: Disorders of the Adrenal Cortex
Chapter 387: Pheochromocytoma
Chapter 388: Multiple Endocrine Neoplasia Syndromes
Chapter 389: Autoimmune Polyendocrine Syndromes

Section 2: Sex- and Gender-Based Medicine
Chapter 390: Sex Development
Chapter 391: Disorders of the Testes and Male Reproductive System
Chapter 392: Disorders of the Female Reproductive System
Chapter 393: Menstrual Disorders and Pelvic Pain
Chapter 394: Hirsutism
Chapter 395: Menopause and Postmenopausal Hormone Therapy
Chapter 396: Infertility and Contraception
Chapter 397: Sexual Dysfunction
Chapter 398: Women’s Health
Chapter 399: Men’s Health
Chapter 400: Lesbian, Gay, Bisexual, and Transgender (LGBT) Health

Section 3: Obesity, Diabetes Mellitus, and Metabolic Syndrome
Chapter 401: Pathobiology of Obesity
Chapter 402: Evaluation and Management of Obesity
Chapter 403: Diabetes Mellitus: Diagnosis, Classification, and Pathophysiology
Chapter 404: Diabetes Mellitus: Management and Therapies
Chapter 405: Diabetes Mellitus: Complications
Chapter 406: Hypoglycemia
Chapter 407: Disorders of Lipoprotein Metabolism
Chapter 408: The Metabolic Syndrome

Section 4: Disorders of Bone and Mineral Metabolism
Chapter 409: Bone and Mineral Metabolism in Health and Disease
Chapter 410: Disorders of the Parathyroid Gland and Calcium Homeostasis
Updated! Chapter 411: Osteoporosis
Chapter 412: Paget’s Disease and Other Dysplasias of Bone
Section 5: Disorders of Intermediary Metabolism
Chapter 413: Heritable Disorders of Connective Tissue
Chapter 414: Hemochromatosis
Chapter 415: Wilson’s Disease
Chapter 416: The Porphyrias
Chapter 417: Disorders of Purine and Pyrimidine Metabolism
Chapter 418: Lysosomal Storage Diseases
Chapter 419: Glycogen Storage Diseases and Other Inherited Disorders of Carbohydrate Metabolism
Chapter 420: Inherited Disorders of Amino Acid Metabolism in Adults
Chapter 421: Inherited Defects of Membrane Transport

Part 13: Neurologic Disorders
Section 1: Diagnosis of Neurologic Disorders
Chapter 422: Approach to the Patient with Neurologic Disease
Chapter 423: Neuroimaging in Neurologic Disorders
Chapter 424: Pathobiology of Neurologic Diseases

Section 2: Diseases of the Central Nervous System
Chapter 425: Seizures and Epilepsy
Chapter 426: Introduction to Cerebrovascular Diseases
Updated! Chapter 427: Ischemic Stroke
Chapter 428: Intracranial Hemorrhage
Chapter 429: Subarachnoid Hemorrhage
Chapter 430: Migraine and Other Primary Headache Disorders
Updated! Chapter 431: Alzheimer’s Disease
Chapter 432: Frontotemporal Dementia
Chapter 433: Vascular Dementia
Chapter 434: Dementia with Lewy Bodies
Updated! Chapter 435: Parkinson’s Disease
Chapter 436: Tremor, Chorea, and Other Movement Disorders
Chapter 437: Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases
Chapter 438: Prion Diseases
Chapter 439: Ataxic Disorders
Chapter 440: Disorders of the Autonomic Nervous System
Chapter 441: Trigeminal Neuralgia, Bell’s Palsy, and Other Cranial Nerve Disorders
Chapter 442: Diseases of the Spinal Cord
Updated! Chapter 443: Concussion and Other Traumatic Brain Injuries
Updated! Chapter 444: Multiple Sclerosis
Chapter 445: Neuromyelitis Optica

Section 3: Nerve and Muscle Disorders
Chapter 446: Peripheral Neuropathy
Updated! Chapter 447: Guillain-Barré Syndrome and Other Immune-Mediated Neuropathies
Chapter 448: Myasthenia Gravis and Other Diseases of the Neuromuscular Junction
Updated! Chapter 449: Muscular Dystrophies and Other Muscle Diseases

Section 4: Chronic Fatigue Syndrome
Chapter 450: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Section 5: Psychiatric and Addiction Disorders
Chapter 451: Biology of Psychiatric Disorders
Chapter 452: Psychiatric Disorders
Chapter 453: Alcohol and Alcohol Use Disorders
Chapter 454: Nicotine Addiction
Chapter 455: Marijuana and Marijuana Use Disorders
Updated! Chapter 456: Opioid-Related Disorders
Chapter 457: Cocaine, Other Psychostimulants, and Hallucinogens

Part 14: Poisoning, Drug Overdose, and Envenomation
Chapter 458: Heavy Metal Poisoning
Chapter 459: Poisoning and Drug Overdose
Chapter 460: Disorders Caused by Venomous Snakebites and Marine Animal Exposures
Chapter 461: Ectoparasite Infestations and Arthropod Injuries

Part 15: Disorders Associated with Environmental Exposures
Chapter 462: Altitude Illness
Chapter 463: Hyperbaric and Diving Medicine
Chapter 464: Hypothermia and Peripheral Cold Injuries
Chapter 465: Heat-Related Illnesses

Part 16: Genes, the Environment, and Disease
Chapter 466: Principles of Human Genetics
Chapter 467: The Practice of Genetics in Clinical Medicine
Chapter 468: Mitochondrial DNA and Heritable Traits and Diseases
Chapter 469: Telomere Disease
Chapter 470: Gene- and Cell-Based Therapy in Clinical Medicine
Chapter 471: The Human Microbiome

Part 17: Global Medicine
Chapter 472: Global Issues in Medicine
Chapter 473: Emerging and Reemerging Infectious Diseases
Chapter 474: Primary Care and Global Health
Chapter 475: Health Effects of Climate Change

Part 18: Aging
Chapter 476: Biology of Aging
Chapter 477: Caring for the Geriatric Patient
Part 19: Consultative Medicine
Chapter 478: Approach to Medical Consultation
Chapter 479: Medical Disorders During Pregnancy
Chapter 480: Medical Evaluation of the Surgical Patient

Part 20: Frontiers
Chapter 481: Behavioral Economics and Health
Chapter 482: Complementary and Integrative Therapies and Practices
Chapter 483: The Role of Epigenetics in Disease and Treatment
Chapter 484: Applications of Stem Cell Biology in Clinical Medicine
Chapter 485: The Role of Circadian Biology in Health and Disease
Chapter 486: Network Medicine: Systems Biology in Health and Disease
Chapter 487: Emerging Neurotherapeutic Technologies
Chapter 488: Machine Learning and Augmented Intelligence in Clinical Medicine
Chapter 489: Metabolomics
Chapter 490: Circulating Nucleic Acids as Liquid Biopsies and Noninvasive Disease Biomarkers
Chapter 491: Protein Folding Disorders
Chapter 492: Novel Approaches to Diseases of Unknown Etiology

Part 21: Video Collection
Chapter V1: Video Library of Gait Disorders
Chapter V2: Primary Progressive Aphasia, Memory Loss, and Other Focal Cerebral Disorders
Chapter V3: Video Library of Neuro-Ophthalmology
Chapter V4: Examination of the Comatose Patient
Chapter V5: Video Atlas of Gastrointestinal Endoscopic Lesions
Chapter V6: The Neurologic Screening Exam
Chapter V7: Video Atlas of the Detailed Neurologic Examination

Part 22: Supplementary Topics
Chapter S1: Fluid and Electrolyte Imbalances and Acid-Base Disturbances: Case Examples
Chapter S2: Cerebrospinal Fluid Disturbances: Case Examples
Chapter S3: Microbial Bioterrorism
Chapter S4: Chemical Terrorism
Chapter S5: Radiation Terrorism
Chapter S6: Infections in War Veterans
Chapter S7: Health Care for Military Veterans
Chapter S8: Primary Immunodeficiencies Associated with (or Secondary to) Other Diseases
Chapter S9: Technique of Lumbar Puncture
Chapter S10: The Clinical Laboratory in Modern Health Care
Chapter S11: Laboratory Diagnosis of Infectious Diseases
Chapter S12: Laboratory Diagnosis of Parasitic Infections

Part 23: Atlases
Chapter A1: Atlas of Rashes Associated with Fever
Chapter A2: Atlas of Blood Smears of Malaria and Babesiosis
Chapter A3: Atlas of Oral Manifestations of Disease
Chapter A4: Atlas of Urinary Sediments and Renal Biopsies
Chapter A5: Atlas of Skin Manifestations of Internal Disease
Chapter A6: Atlas of Hematology
Chapter A7: Atlas of Electrocardiography
Chapter A8: Atlas of Cardiac Arrhythmias
Chapter A9: Atlas of Noninvasive Imaging
Chapter A10: Atlas of Atherosclerosis
Chapter A11: Atlas of Percutaneous Revascularization and Adult Structural Heart Interventions
Chapter A12: Atlas of Chest Imaging
Chapter A13: Atlas of Liver Biopsies
Chapter A14: Atlas of the Vasculitic Syndromes
Chapter A15: Atlas of Clinical Manifestations of Endocrine and Metabolic Diseases
Chapter A16: Atlas of Neuroimaging

Part 24: Clinical Procedure Tutorials
Chapter CP1: Clinical Procedure Tutorial: Central Venous Catheter Placement
Chapter CP2: Clinical Procedure Tutorial: Thoracentesis
Chapter CP3: Clinical Procedure Tutorial: Abdominal Paracentesis
Chapter CP4: Clinical Procedure Tutorial: Endotracheal Intubation
Chapter CP5: Clinical Procedure Tutorial: Percutaneous Arterial Blood Gas Sampling
Chapter CP6: Clinical Procedure Tutorial: Lumbar Puncture
Chapter CP7: Clinical Procedures Tutorial: Phlebotomy
Chapter CP8: Clinical Procedures Tutorial: Insertion of Female Urethral Catheter
Chapter CP9: Clinical Procedures Tutorial: Insertion of Male Urethral Catheter
Chapter CP10: Clinical Procedures Tutorial: Fine Needle Aspiration of Breast Cyst
Chapter CP11: Clinical Procedures Tutorial: IV Insertion
Chapter CP12: Clinical Procedures Tutorial: Fine Needle Aspiration of Thyroid Nodules
Chapter CP13: Clinical Procedures Tutorial: Gynecologic Examination with Pap Smear
Chapter CP14: Clinical Procedures Tutorial: Knee Arthrocentesis
Chapter CP15: Clinical Procedures Tutorial: Pericardiocentesis
Chapter CP16: Clinical Procedures Tutorial: Bone Marrow Biopsy
Chapter CP17: Clinical Procedures Tutorial: Basic Suturing

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